Anticancer Agent Women Anabolic Steroids Powder Eplerenone Cas 107724 20 9
Eplerenone Basic Info
Product Name: Eplerenone
Appearance: White solid
Density: 1.31 g/cm3
Melting Point: 241-243 ° C
Boiling Point: 597.933 ° C at 760 mmHg
Flash Point: 259.474 ° C
Storage: Keep it under seal in cool and dark place
Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.
Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM. It is used as an adjunct in the management of chronic heart failure. It is similar to the diuretic spironolactone, though it may be more specific for the mineralocorticoid receptor.
Common adverse drug reactions (ADRs) associated with the use of eplerenone include: hyperkalaemia,
hypotension, dizziness, altered renal function, and increased creatinine concentration. Eplerenone may
have a lower incidence of sexual side effects such as feminization, gynecomastia, impotence, low sex
drive and reduction of size of male genitalia. Due to the high risk of elevated potassium levels in
individuals taking eplerenone, the United States FDA suggests routine checks on the individual's
potassium level to screen for hyperkalemia.
Eplerenone (INN) is an aldosterone antagonist used as an adjunct in the management of chronic heart
failure. It is similar to the diuretic spirono lactone, though it is much more selective for the
mineralocorticoid receptor in comparison (i.e., does not possess any antiandrogen, progestogen, or
estrogenic effects), and is specifically marketed for reducing cardiovascular risk in patients following
myocardial infarction. It is marketed by Pfi zer under the trade name Inspra. Eplerenone is a potassium-sparing diuretic, meaning that it helps the body get rid of water but still keep potassium.
||A white or almost white crystalline powder, freely soluble in water,
sparingly soluble in alcohol, insoluble in aether or chloroform.
||IR ,UV ,HPLC-Rt
|Water (by K.F)
|Loss on drying
|Residue on ignition
||Single impurity :0.3%Max
Total impurities :1.0%Max
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